Down syndrome is a hereditary and congenital disease usually associated with Trisomy 21.
Children with the disease usually show the foolowing characteristics:
1)Extensive mental retardation
2)Craniofacial Abnormalities
3)Small ears
4)Flat faces
5)Cardiac defects
6)Hypotonia(low muscle tone)
7) Folds of skin on the medial side of the eyes
These individual also show signs of thyroid dysfunction,high levels of leukemia and also premature aging.
Down syndrome is usually caused by trisomy 21 where an additional chromosome is added to the normal number of chromosomes at chromosome number 21.(Remember that trisomy 21 is a type of aneuploidy,a chromosomal abnormality). Trisomy 21 is caused by meiotic non disjunction during fertilization.
Down syndrome is usually noticed in children born by women 35 years of age and above.The prevalence of the disease in younger women is rare,about 1 in 2000 live births.
Children with the disease usually show the foolowing characteristics:
1)Extensive mental retardation
2)Craniofacial Abnormalities
3)Small ears
4)Flat faces
5)Cardiac defects
6)Hypotonia(low muscle tone)
7) Folds of skin on the medial side of the eyes
These individual also show signs of thyroid dysfunction,high levels of leukemia and also premature aging.
Down syndrome is usually caused by trisomy 21 where an additional chromosome is added to the normal number of chromosomes at chromosome number 21.(Remember that trisomy 21 is a type of aneuploidy,a chromosomal abnormality). Trisomy 21 is caused by meiotic non disjunction during fertilization.
Down syndrome is usually noticed in children born by women 35 years of age and above.The prevalence of the disease in younger women is rare,about 1 in 2000 live births.
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